CHRONIC MANGANESE EXPOSURE THROUGH WELL WATER AND ITS ASSOCIATION WITH NEUROLOGICAL SYMPTOMS IN PADANG, INDONESIA

Authors

  • Azyyati Ridha Alfian Universitas Andalas
  • Athifa Midra Nandra Environmental Health and Occupational Health Department of Public Health Faculty, Andalas University
  • Nadifah Khairini Fahdi Environmental Health and Occupational Health Department of Public Health Faculty, Andalas University
  • Fea Firdani Environmental Health and Occupational Health Department of Public Health Faculty, Andalas University
  • Aria Gusti Environmental Health and Occupational Health Department of Public Health Faculty, Andalas University

DOI:

https://doi.org/10.55766/sujst9528

Keywords:

Health, Lead, Manganese, Neurotoxic Symptoms, Water

Abstract

Heavy metal contamination in groundwater is a major public health issue in Indonesia. Data reveals that roughly 10,683 villages/sub-districts have water contamination, with over 6,000 impacted by residential waste and around 4,500 by industrial waste. This study aimed to assess manganese and lead levels in well water and explore their association with neurotoxic symptoms (motor distractions) in a community in Padang. A cross-sectional survey was conducted among 116 households. Well water samples were tested using Atomic Absorption Spectrophotometry (AAS) and neurotoxic symptoms were assessed via a structured questionnaire. A chi-square test was employed to investigate the correlation between metal concentrations and reported symptoms, uncovering substantial relationships despite constraints in biomarker analysis. 70% of Mn and 47.3% of Pb samples exceeded national standards. A statistically significant association was found between elevated Mn levels and neurotoxic symptoms (OR=3.7; p=0.032), while Pb levels showed no significant association (p=0.4). Chronic exposure to manganese through well water was linked to increased neurotoxic symptoms. Further research using clinical and biomarker assessments is recommended.

References

Arbi, Y., Siregar, R., Leonardo, & Damanhuri, T. (2018). Kajian pencemaran air tanah oleh lindi di sekitar Air Dingin Kota Padang. Sains dan Teknologi: Jurnal Keilmuan dan Aplikasi Teknologi Industri, 18(1), 46-52. https://doi.org/10.36275/stsp.v18i1.99

Ashar, T. (2007). Analisis risiko asupan oral pajanan mangan dalam air terhadap kesehatan masyarakat. Jurnal Kesehatan Masyarakat Nasional, 2(3), 123-130. https://doi.org/10.21109/kesmas.v2i3.265

Besnaya, Z. (2019). Studi penyebaran kontaminan Pb dan Fe dari lindi pada air tanah dangkal TPA Payakumbuh. Jurnal Aerasi, 1(1), 7-13. https://doi.org/10.36275/jaerasi.v1i1.136

Bouchard, M. F., Sauvé, S., Barbeau, B., Legrand, M., Brodeur, M. É., Bouffard, T., Limoges, E., Bellinger, D. C., & Mergler, D. (2011). Intellectual impairment in school-age children exposed to manganese from drinking water. Environmental Health Perspectives, 119(1), 138-143. https://doi.org/10.1289/ehp.1002321

Burton, N. C., & Guilarte, T. R. (2009). Manganese neurotoxicity: Mechanisms of injury, treatment, and prevention. Current Environmental Health Reports, 6, 107-115. https://doi.org/10.1007/s40572-019-00240-1

Caudle, W. M., Guillot, T. S., Lazo, C. R., & Miller, G. W. (2012). Industrial toxicants and Parkinson’s disease. Neurotoxicology, 33(2), 178-188. https://doi.org/10.1016/j.neuro.2012.01.010

Central Bureau of Statistics. (2020). Statistik lingkungan hidup Indonesia: Air dan lingkungan. Badan Pusat Statistik.

Central Bureau of Statistics. (2021). Statistik potensi desa Indonesia 2021. Badan Pusat Statistik.

Chen, P., Bornhorst, J., & Aschner, M. (2021). Manganese metabolism in humans. International Journal of Molecular Sciences, 22(9), 4646. https://doi.org/10.3390/ijms22094646

Cheng, C., Zhang, F., Shi, J., & Kung, H. T. H. (2022). What is the relationship between land use and surface water quality? A review and prospects from a remote sensing perspective. Environmental Science and Pollution Research, 29(38), 56887-56907. https://doi.org/10.1007/s11356-022-21348-x

Dribben, W. H., Creeley, C. E., & Farber, N. (2011). Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain. Neurotoxicology and Teratology, 33(4), 473-480. https://doi.org/10.1016/j.ntt.2011.05.006

Febrina, L., & Ayuna, A. (2014). Studi penurunan kadar besi (Fe) dan mangan (Mn) dalam air tanah menggunakan saringan keramik. Jurnal Teknologi, 7(1), 36-44.

Fernandes, J., & Zheng, W. (2023). Manganese-induced neurotoxicity: Mechanisms of action and potential therapeutic strategies. Neurotoxicology, 96, 32-45.

Ferreira, A. P. S., de Souza, F. M., Gomes, T. M. A., & Almeida, R. M. R. (2022). Heavy metal contamination in groundwater from landfill sites in Brazil: Health risk assessment. International Journal of Environmental Research and Public Health, 19(21), 13865. https://doi.org/10.3390/ijerph192113865

Guilarte, T. R. (2013). Manganese and Parkinson’s disease: A critical review and new findings. Toxicology, 349-350, 1-17. https://doi.org/10.1016/j.tox.2013.03.001

Handriyani, K. A. T. S., Habibah, N., & Dhyanaputri, I. G. A. S. (2020). Analisis kadar timbal (Pb) pada air sumur gali di kawasan tempat pembuangan akhir sampah Banjar Suwung Batan Kendal Denpasar Selatan. Jurnal Sains dan Teknologi, 9(1), 68-75. https://doi.org/10.23887/jstundiksha.v9i1.17842

Hartini, E. (2012). Cascade aerator dan bubble aerator dalam menurunkan kadar mangan air sumur gali. Jurnal Kesehatan Masyarakat, 8(1), 42-50.

Heny, D. K. N., Dhanti, K. R., & Wardani, D. P. K. (2022). Analisis kandungan timbal (Pb) pada air sumur di sekitar tempat pembuangan akhir Kalipancur Kabupaten Purbalingga. Jurnal Analis Medika Biosains, 9(1), 1-8. https://doi.org/10.32807/jambs.v9i1.224

Jasman. (2011). Uji coba biji kelor (Moringa oleifera) untuk menurunkan kadar besi (Fe) dan mangan (Mn) dalam air. Jurnal Ilmu Kesehatan, 6(1), 1-10.

Li, W., Wang, Z., Zhang, X., Liu, Y., & Wang, C. (2022). Role of α-synuclein in manganese-induced dopaminergic neurodegeneration: Implications for synaptic dysfunction and Parkinsonian symptoms. Frontiers in Pharmacology, 13, 1011947. https://doi.org/10.3389/fphar.2022.1011947

Menteri Kesehatan Republik Indonesia. (2023). Peraturan Menteri Kesehatan Republik Indonesia Nomor 2 Tahun 2023 tentang peraturan pelaksanaan Peraturan Pemerintah Nomor 66 Tahun 2014 tentang kesehatan lingkungan.

Misa, A., Duka, R., Layuk, S., & Kawatu, Y. (2019). Hubungan kedalaman sumur bor dengan kadar besi (Fe) dan mangan (Mn) di Kelurahan Malendeng Kecamatan Paal 2 Kota Manado. Jurnal Kajian Pendidikan Ekonomi dan Ilmu Ekonomi, 9(1), 62-68. https://doi.org/10.47718/jkl.v9i1.644

Musrawati, M. (2016). Identifikasi kandungan logam Pb dalam air sumur di sekitar TPA Cadika dengan metode SSA. ILTEK: Jurnal Teknologi, 11(2), 1664-1667. https://doi.org/10.47398/iltek.v11i02.434

Nora, N., Maksuk, M., & Amin, M. (2022). Analisis pencemaran logam berat timbal (Pb) pada air sumur gali masyarakat di sekitar tempat pembuangan akhir Sukawinatan. Jurnal Sanitasi Lingkungan, 2(2), 79-84. https://doi.org/10.36086/jsl.v2i2.877

Noviandi. (2012). Analisis risiko kandungan mangan pada air minum dari sumur gali terhadap Parkinson-like syndrome di Desa Amplas Kecamatan Percut Sei Tuan Kabupaten Deli Serdang [Skripsi, Universitas].

Peres, T. V., Schettinger, M. R. C., Chen, P., Carvalho, F., Avila, D. S., Bowman, A. B., & Aschner, M. (2016). Manganese-induced neurotoxicity: A review of its behavioral consequences and neuroprotective strategies. BMC Pharmacology and Toxicology, 17(1), 57. https://doi.org/10.1186/s40360-016-0099-0

Pyatha, S., Kim, H., Lee, D., & Kim, K. (2022). Association between heavy metal exposure and Parkinson’s disease: A review of the mechanisms related to oxidative stress. Antioxidants, 11(12), 2467. https://doi.org/10.3390/antiox11122467

Qadriyah, L., Moelyaningrum, A. D., & Ningrum, P. T. (2019). Kadar kadmium pada air sumur gali di sekitar tempat pemrosesan akhir sampah Kabupaten Jember. BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan), 6(1), 41-49. https://doi.org/10.31289/biolink.v6i1.2400

Sarkar, S., Rahman, M. M., Ahmed, F., & Hossain, M. B. (2024). Iron, manganese and lead contamination in drinking water in Bangladesh: Human health risks and sustainability challenges. Water Practice and Technology, 19(3), 745–757. https://doi.org/10.2166/wpt.2024.030

Seppäläinen, A. M., Hernberg, S., Vesanto, R., & Kock, B. (1983). Early neurotoxic effects of occupational lead exposure: A prospective study. Neurotoxicology, 4(2), 181-192.

Shvachiy, L., Geraldes, V., & Outeiro, T. F. (2023). Uncovering the molecular link between lead toxicity and Parkinson’s disease. Antioxidants & Redox Signaling, 39(4-6), 321-335. https://doi.org/10.1089/ars.2022.0076

Sidoryk-Wegrzynowicz, M., & Aschner, M. (2013). Manganese toxicity in the central nervous system: The glutamine/glutamate–γ-aminobutyric acid cycle. Journal of Internal Medicine, 273(5), 466-477. https://doi.org/10.1111/joim.12041

Siswoyo, E., & Habibi, G. F. (2018). Sebaran logam berat cadmium (Cd) dan timbal (Pb) pada air sungai dan sumur di daerah sekitar tempat pembuangan akhir Wukirsari Gunung Kidul, Yogyakarta. Journal of Natural Resources and Environmental Management, 8(1), 1-6. https://doi.org/10.29244/jpsl.8.1.1-6

Sriram, K., Lin, G. X., Jefferson, A. M., Roberts, J. R., Chapman, R. S., Chen, B. T., & Antonini, J. M. (2010). Environmental manganese exposure and neuroinflammation in Parkinson’s disease. Journal of Neurochemistry, 114(6), 1558-1571. https://doi.org/10.1111/j.1471-4159.2010.06881.x

Sunarto, N. D. (2021). Analisis kandungan zat besi dan kadar mangan pada air sumur masyarakat di Dusun V Bandar [Skripsi, Universitas Islam Negeri].

Supandi, G. A. (2022). Uji kandungan beberapa unsur logam berat pada air irigasi, tanah dan sayuran kangkung (Ipomoea aquatica Forsk) di kawasan industri Kecamatan Margaasih Kabupaten Bandung. Biosfer: Jurnal Biologi dan Pendidikan Biologi, 7(2). https://doi.org/10.23969/biosfer.v7i2.6820

Tarigan, L. (2015). Analisis risiko kesehatan lingkungan mangan pada air bersih masyarakat Desa Supul Kecamatan Kuatnana Kabupaten Timor Tengah Selatan.

Tong, S., von Schirnding, Y. E., & Prapamontol, T. (2000). Environmental lead exposure: A public health problem of global dimensions. Bulletin of the World Health Organization, 78(9), 1068-1077.

Tumanggor, W. R. E., Dharma, S., & Marsaulina, I. (2012). Analisis kandungan Pb pada air sumur gali masyarakat di sekitar tempat penimbunan limbah padat industri timah dari daur ulang aki bekas. Jurnal Undiksha, 12(1), 1-7.

Ullah, I., Zhao, L., Hai, Y., Fahim, M., Alwayli, D., Wang, X., & Li, H. (2021). Metal elements and pesticides as risk factors for Parkinson’s disease: A review. Toxicology Reports, 8, 607–616. https://doi.org/10.1016/j.toxrep.2021.03.009

Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Levy, D., Factor-Litvak, P., Kline, J., van Geen, A., Mey, J. L., Slavkovich, V., Islam, T., & Graziano, J. H. (2006). Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh. Environmental Health Perspectives, 114(1), 124-129. https://doi.org/10.1289/ehp.8030

Weisskopf, M. G., Weuve, J., Nie, H., Saint-Hilaire, M. H., Sudarsky, L., Simon, D. K., Hersh, B., Schwartz, J., Wright, R. O., & Hu, H. (2010). Association of cumulative lead exposure with Parkinson’s disease. Environmental Health Perspectives, 118(11), 1609-1613. https://doi.org/10.1289/ehp.1002339

World Health Organization. (1977). Environmental health criteria 3: Lead. World Health Organization.

World Health Organization. (2017). Pedoman kualitas air minum.

Yu, X., Zhang, J., Li, D., & Wang, Z. (2022). Neuroinflammation in manganese-induced neurotoxicity: The role of oxidative stress and the NLRP3 inflammasome pathway. Toxicology Letters, 369, 1-9.

Zhang, X., Chen, Y., Wang, S., Liu, H., & Huang, Q. (2023). Assessment of groundwater quality near landfills using heavy metal indicators and pollution indices. Water, 15(2), 572. https://doi.org/10.3390/w15020572

Zhou, Y., Zhang, Y., Pan, X., Yang, Y., & Zhang, Q. (2014). Maternal exposure to manganese and the risk of birth defects in offspring. Environmental Health Perspectives, 122(5), 488-494.

Zhu, Z. W., Yang, R. L., Dong, G. J., & Zhao, Z. Y. (2005). Study on the neurotoxic effects of low-level lead exposure in rats. Journal of Zhejiang University Science B, 6(7), 686-692. https://doi.org/10.1631/jzus.2005.B0686

Downloads

Published

2026-02-09

How to Cite

Alfian, A. R., Midra Nandra, A., Khairini Fahdi, N., Firdani, F., & Gusti, A. (2026). CHRONIC MANGANESE EXPOSURE THROUGH WELL WATER AND ITS ASSOCIATION WITH NEUROLOGICAL SYMPTOMS IN PADANG, INDONESIA. Suranaree Journal of Science and Technology, 32(6), 070095(1–9). https://doi.org/10.55766/sujst9528

Issue

Section

Research Article

Categories