IN-SILICO INVESTIGATION BASED PLANT SECONDARY METABOLITES AS PROMISING IMMUNOSTIMULANTS AGAINST COVID-19
Keywords:
Immunostimulants, SARS-CoV-2, COVID-19, terpenoids, flavonoids, ACE2, PAK1, proteasesAbstract
Objectives: The present study is focused to introduce a better preventive and treatment prospective to fight against the COVID-19 crisis by improving the immune system along with inhibiting the viral activity by a comprehensive review and supportive in-silico study. Methodology: The study was conducted with a systemic review on the phytochemicals possessing immunostimulatory potentiality, which was further supported by an in-silico investigation of thosephytocomponents in improving the immunity of the patient as well as in preventive measures which cancontribute a major part to manage the dangerous consequences of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Results: In in-silico study showed that scutellarein, hesperidin andbaicalin exhibited strong binding affinity with ACE2, PAK1, Protease by strong molecular interaction forming several hydrogen bonds. Conclusion: The present finding interprets scutellarein, hesperidin and baicalin to be potential herbal immune boosters with antiviral potentiality which are to be further explored by in-vitro and in-vivo methods.
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