NOVEL PRECLINICAL PHARMACOLOGICAL SCREENING MODELS FOR ANTI-ULCER ACTIVITY WITH EMERGING THERAPEUTIC TARGETS
Peptic Ulcer: Screening Models and Applications
DOI:
https://doi.org/10.55766/sujst6602Keywords:
H. pylori, Histamine, in vitro, Peptic ulcer in vivo, Protective, StomachAbstract
A peptic ulcer is a gastrointestinal disorder that causes discomfort, morbidity, and mortality in humans as a result of unhealthy food, smoking, alcohol intake, frequent use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Helicobacter pylori (H. pylori), and a sedentary lifestyle. Ulceration forms in the stomach, or duodenum, when there is an imbalance between the protective factors of the gastroduodenal mucosa, such as bicarbonate and mucus, and the offensive factors, such as stomach acid and pepsin synthesis. This results in the development of tiny lesions that cause pain. So, it requires effective therapeutic strategies. There are several approaches for assessing the anti-ulcer activity of natural or synthetic drugs. These strategies are known as experimental animal models. The primary objective of this review is to explain the different types of models, such as in vivo and in vitro, that have been utilized to produce gastric and duodenal ulcers to identify the healing features and properties of various innovative and current medications. This review also discusses the principles, procedures, applications, and parameters of different types of models. In addition, it also delves into the advantages, disadvantages, and challenges related to the use of these screening models.
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