HISTOLOGICAL AND HISTOCHEMISTRY COMPARISONS BETWEEN MEDIAL AND LATERAL MENISCI IN OSTEOARTHRITIS PATIENTS
DOI:
https://doi.org/10.55766/sujst-2024-04-e03380Keywords:
Osteoarthritis, Cartilage, Meniscus, Pathology, ApoptosisAbstract
Osteoarthritis (OA) is a joint disease affecting articular cartilage, menisci, and other joint components. The main objective of this study was to investigate structural and biochemical changes in the medial and lateral menisci of Thai OA patients. Histologically, the bone marrow-like structure was mainly observed at the posterior horn of both medial and lateral menisci. The numbers of meniscal cells were significantly lower at the posterior and anterior horns of the medial and menisci, respectively. Cells at the posterior horn of the medial meniscus were significantly hypertrophied. A decrease in proteoglycan was observed mainly at the posterior horn of both medial and lateral menisci, while collagen fibers markedly increased at the posterior horn of the medial meniscus. Moreover, apoptotic cells were significantly higher in numbers at the posterior and anterior horns of the lateral and medial menisci respectively. The results revealed that the pathology of OA occurred mostly at the posterior horn of the medial meniscus.
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