CHARACTERIZATION OF PIEZOCERAMIC-HYDROXYAPATITE COMPOSITES FOR BONE TISSUE ENGINEERING

Manita  Boonchoo; Piyanan  Boonphayak; Jirapa  Tangsritrakul

Authors

Manita Boonchoo Faculty of Science and Technology, Thammasat University, Phahonyothin Rd, Khlong Nueng, Khlong Luang District, Pathum Thani 12120, Thailand.
Piyanan Boonphayak Department of Industrial Engineering, Engineering Faculty, Naresuan University, Phitsanulok 65000, Thailand.
Jirapa Tangsritrakul Faculty of Science and Technology, Thammasat University, Phahonyothin Rd, Khlong Nueng, Khlong Luang District, Pathum Thani 12120, Thailand.

Keywords:

Lead-free piezoceramics, electrical properties, biomaterials, bone-repair applications

Abstract

Hydroxyapatite(HA)hasbeenwidelyusedasbonerepairingmaterial,asitschemicalcompositionresembleshumanbonecomposition.However,differentclinicalreportsrevealthatpureHAhasalowboneinductionwhilehavinglowmechanicalproperties;inaddition,itisunderstoodbyscientistthatpiezoelectricpropertiescanbeobservedinhumanbonetissue.Therefore,thisstudyanticipatesthatuseofthepiezoelectriceffectinlead-freepiezoceramicswouldbefeasibleforbonerepairapplications.Thecrystalstructure,microstructure,andelectricalpropertiesofbariumtitanate(BT),bariumcalciumzirconatetitanate(BCZT),90BT-10HAcompositesand90BCZT-10HAcompositeswerethereforeinvestigated.X-raydiffraction(XRD)patternsrevealedthatapureperovskitephasewasobservedinpureBTandBCZTceramics,whileHAdecompositionwasfoundin90BT-10HAand90BCZT-10HAceramics.Furthermore,additionofHAintoBTandBCZTceramicscausedadecreaseinaveragegrainsizeanddielectricpermittivityaswellaspolarization.Insummary,resultsshowedthat90BT-10HAceramicsisapromisingcandidateforuseinboneimplantsandforbonerepairapplications,sinceitexhibitedgooddielectricpermittivityandpolarization.

References

Ahmad, N., Tsuru, K., Munar, M.L., Maruta, M., Matsuya, Kunio Ishikawa, S. (2012). Effect of precursor’s solubility on the mechanical property of hydroxyapatite formed by dissolution-precipitation reaction of tricalcium phosphate. Dental Mat. J., 31(6):995-1,000.

Bai, Y., Matousek, A., Tofel, P., Bijalwan, V., Nan, B., Hughes, H., and Button, T.W. (2015). (Ba,Ca)(Zr,Ti)O3 lead-free piezoelectric ceramics-The critical role of processing on properties. J. Euro. Cer. Soc., 35(13):3,445-3,456.

Baxter, F.R., Turner, I.G., Bowen, C.R., Gittings, J.P., and Chaudhuri, J.B. (2009). An in vitro study of electrically active hydroxyapatite-barium titanate ceramics using Saos-2 cells. J. Mat. Sci.: Mat. Med., 20(8):1,697-1,708.

Bose, S., Roy, M., and Bandyopadhyay, A. (2012). Recent advances in bone tissue engineering scaffolds. Trends Biotechnol., 30(10):546-554.

Chen, C., Zhuang, H., Zhu, X., Zhang, D., Zhou, K., and Yan, H. (2015). Effect of Ca substitution sites on dielectric properties and relaxor behavior of Ca doped barium strontium titanate ceramics. J. Mat. Sci.: Mat. Electro., 26(4):2,486-2,492.

Cheng, B.L., Wang, C., Wang, S.Y., Lu, H.B., Zhou, Y.L., Chen, Z.H., and Yang, G.Z. (2005). Dielectric properties of (Ba0.8Sr0.2)(ZrxTi1−x)O3 thin films grown by pulsed-laser deposition. J. Euro. Cer. Soc., 25(12):2,295-2,298.

Dosen, A. and Giese, R.F. (2011). Thermal decomposition of brushite, CaHPO4·2H2O to monetite CaHPO4 and the formation of an amorphous phase. Amer. Mineral., 96(2-3):368-373.

Fukada, E. and Yasuda, I. (1957). On the piezoelectric effect of bone. J. Phys. Soc. Japan, 12(10):1,158-1.162.

Gittings, J.P., Bowen, C.R., Dent, A.C.E., Turner, I.G., Baxter, F.R., and Chaudhuri, J.B. (2009). Electrical characterization of hydroxyapatite-based bioceramics. Acta Biomat., 5(2):743-754.

Gittings, J.P., Bowen, C.R., Turner, I.G., Baxter, F., and Chaudhuri, J. (2007). Characterisation of ferroelectric-calcium phosphate composites and ceramics. J. Euro. Cer. Soc., 27(13-15):4,187-4,190.

Jacob, J., More, N., Kalia, K., and Kapusetti, G. (2018). Piezoelectric smart biomaterials for bone and cartilage tissue engineering. Inflamm. Regener., 38(1).

Keswani, B.C., Saraf, D., Patil, S.I., Kshirsagar, A., James, A.R., Kolekar, Y.D., and Ramana, C.V. (2018). Role of A-site Ca and B-site Zr substitution in BaTiO3 lead-free compounds: Combined experimental and first principles density functional theoretical studies. J. Appl. Phys., 123(20):204104.

Li, W., Xu, Z., Chu, R., Fu, P., and Zang, G. (2010). Piezoelectric and Dielectric Properties of (Ba1-xCax)(Ti0.95Zr0.05)O3 Lead-Free Ceramics. J. Amer. Cer. Soc., 93(10):2,942-2,944.

Nakamura, M., Niwa, K., Nakamura, S., Sekijima, Y., and Yamashita, K. (2007). Interaction of a blood coagulation factor on electrically polarized hydroxyapatite surfaces. J. Biomed. Mat. Res. Part B: Appl. Biomat., 82B(1):29-36.

Ou, S.-F., Chiou, S.-Y., and Ou, K.-L. (2013). Phase transformation on hydroxyapatite decomposition. Cer. Int., 39(4):3,809-3,816.

Parjansri, P., Intatha, U., and Eitssayeam, S. (2015). Dielectric, ferroelectric and piezoelectric properties of Nb5+ doped BCZT ceramics. Mat. Res. Bull., 65:61-67.

Park, J.B., Kenner, G.H., Brown, S.D., and Scott, J.K. (1977). Mechanical property changes of barium titanate (ceramic) after in vivo and in vitro aging. Biomat. Med. Devic. Artif. Org., 5(3):267-276.

Phromyoo, S., Lertcumfu, N., Jaita, P., Jarupoom, P., Pengpat, K., and Rujijanagul, G. (2018). Effects of barium zirconium titanate on the properties of β-tricalcium phosphate bioceramics. Cer. Int., 44(3):2,661-2,667.

Prakasam, M., Albino, M., Lebraud, E., Maglione, M., Elissalde, C., and Largeteau, A. (2017). Hydroxyapatite-barium titanate piezocomposites with enhanced electrical properties. J. Amer. Cer. Soc., 100(6):2,621-2,631.

Rajabi, A.H., Jaffe, M., Arinzeh, and T.L., (2015). Piezoelectric Materials for Tissue Regeneration: A Review. Acta Biomater., 24:12-23. doi: 10.1016/j.actbio.2015.07.010.

Senra, M.R., Lima, R.B. de, Souza, D. de H.S., Marques, M. de F.V., and Monteiro, S.N. (2020). Thermal characterization of hydroxyapatite or carbonated hydroxyapatite hybrid composites with distinguished collagens for bone graft. J. Mat. Res. Technol., 9(4):7,190-7,200.

Sikder, P., Koju, N., Lin, B., and Bhaduri, S.B. (2019). Conventionally Sintered Hydroxyapatite-Barium Titanate Piezo-Biocomposites Transactions of the Indian Institute of Metals. 72:2,011-2,018. DOI: 10.1007/S12666-018-1533-3.

Stewart, M., Cain, M., and Hall, D. (1999). Ferroelectric Hysteresis Measurement And Analysis. NPL Report CMMT(A) 152, 51p.

Suchanek, W. and Yoshimura, M. (1998). Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J. Mat. Res., 13(01):94-117.

Tang, Y., Wu, C., Wu, Z., Hu, L., Zhang, W., and Zhao, K. (2017). Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration. Scientific Reports, 7:43360.

Tavangar, M., Heidari, F., Hayati, R., Tabatabaei, F., Vashaee, D., and Tayebi, L., (2020). Manufacturing and characterization of mechanical, biological and dielectric properties of hydroxyapatite-barium titanate nanocomposite scaffolds. Cer. Int., 46(7):9,086-9,095.

Vouilloz, F.J., Castro, M.S., Vargas, G.E., Gorustovich, A., and Fanovich, M. A. (2017). Reactivity of BaTiO3 -Ca10(PO4)6 (OH)2 phases in composite materials for biomedical applications. Cer. Int., 43(5):4,212-4,221.

Wang, P., Li, Y., and Lu, Y. (2011). Enhanced piezoelectric properties of (Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 lead-free ceramics by optimizing calcination and sintering temperature. J. Euro. Cer. Soc., 31(11):2,005-2,012.

Wu, J., Xiao, D., Wu, W., Chen, Q., Zhu, J., Yang, Z., and Wang, J. (2012). Composition and poling condition-induced electrical behavior of (Ba0.85Ca0.15)( Ti1-xZrx)O3 lead-free piezoelectric ceramics. J. Euro. Cer. Soc., 32(4):891-898.

Yang, T., Ke, X., and Wang, Y. (2016). Mechanisms Responsible for the Large Piezoelectricity at the Tetragonal-Orthorhombic Phase Boundary of (1-x)BaZr0.2Ti0.8O3-xBa0.7Ca0.3TiO3 System. Scientific Reports, 6(1).

Zhou, H. and Lee, J. (2011). Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomat., 7(7):2,769-2,781.