NANOFIBROUS SCAFFOLDS OF ELECTROSPUN SILK FIBROIN/POLY(VINYL ALCOHOL) BLENDS FOR TISSUE ENGINEERING
Keywords:
Nanofibrous, electrospinning, scaffold, tissue engineering, meniscusAbstract
Electrospinningisabeneficialpolymerfabricationprocess.Itisapplicableforelectrospunnanofibrousscaffoldwhichcanmimicnano-scalefibrouscomponentintheextracellularmatrixofmanytissues.Silkfibroin(SF)isafibrousprotein,mainlyproducedbysilkworms.SFiscomposedofbeta-sheetcrystallineandamorphousmatrix.Itpossessesexcellentbiocompatibility,biodegradability,andcellinductionproperty.Therefore,SFisapromisingresourceforbiomedicalmaterials.Polyvinylalcohol(PVA)isasemicrystallinehydrophilicpolymer.Accordingtotheirmechanicalpropertiesandnon-toxicity,PVAisgoodcandidatetouseinahighscaffoldthatrequiredhighmechanicalstrength.Inourresearch,theSF/PVAcompositescaffoldwasfabricatedusingelectrospinningtechnique,aimedtodevelopedbiomimeticscaffoldofthemeniscus,afibrocartilageinthekneejoint,whichprovidedgoodbiologicalandmechanicalproperties.ThisstudyfocusedontheeffectofPVAcontentsinSF/PVAnanofibrousscaffold.Theprocessability,morphologyandhydrophilicityofSF/PVAnanofibersweredetermined.TheresultsshowedadecreaseinwatercontactanglewithincreasingPVAcontentintheSF/PVAnanofibers.TheresultsalsosuggestthatahighPVAcontentintheSF/PVAnanofiberscanenhancethecellattachmentcapabilityofthescaffold.
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