EFFECTS OF MANGOSTEEN HULL EXTRACTS ON BIOEFFICACY AND ANTIPROLIFERATION OF HUMAN BREAST AND PROSTATE CARCINOMA CELL LINES
Keywords:
Garcinia mangostana, antioxidation, antiproliferation, cytotoxicityAbstract
This study aimed to investigate the benefits of methanolic and ethanolic mangosteen(Garcinia mangostana L.) hull extracts (MHE/m and MHE/e) for medicinal properties. The results found that MHE/m contained total phenolic compounds and flavonoids contents greater than MHE/e. Also, the free radical scavenging activity and lipid peroxidative inhibition of MHE/m were higher than those of MHE/e, but the values were significantly lower than the antioxidant standards such catechin (CA) and epigallocatechin-3-gallate(EGCG). The study of antiproliferation on human MCF-7 breast and PC-3 prostate cancer cell lines via MTT and the resazurin method found that the MHEs could inhibit both cancer cell lines better than CA, but worse than EGCG. As for the cytotoxicity test via brine shrimp and mosquito larvae lethality assays, the MHEs were more toxic on the brine shrimp and mosquito larvae. In conclusion, it indicates that MHEs can exhibit different activities and have the potential for antiproliferation on MCF-7 breast and PC-3 prostate cancer cell lines which were in a dose-dependent manner.
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