THE STUDY OF ANTIBACTERIAL ACTIVITY OF SOME MEDICINAL PLANTS IN LAMIACEAE FAMILY
Keywords:
Lamiaceae, drug-resistant bacteria, MIC, FIC, macrodilution test, checkerboard assayAbstract
The presence of drugs-resistant bacteria did not only hamper the effective treatment of infectious diseases,
but also increased the cost of treatment. Therefore, there is a need to develop alternative antimicrobial
drugs for the treatment of infectious diseases. In this study, four species of Lamiaceae, namely, Mentha
cordifolia Opiz ex Fresen, Ocimum basilicum L., O. basilicum L. forma citratum Back and Hyptis
suaveolens (L.) Poit were examined individually for the antibacterial study and the synergistic effect
against drugs-susceptible and drugs-resistant clinical isolates of bacteria. All of these four medicinal
plants showed antibacterial activities against all clinical isolated test bacteria. H. suaveolens (L.) Poit
individually displayed the best antibacterial activity against Methicillin-resistant Staphylococcus aureus.
H. suaveolens (L.) Poit in combination with O. basilicum L. showed synergistic effect against
Ciprofloxacin-resistant Pseudomonas aeruginosa. Further investigation on laboratory and clinical studies
are required to elucidate the data for the development of their uses as alternative sources of antimicrobial
agent.
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