DENDRIMERS IN NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW
DOI:
https://doi.org/10.55766/sujst-2023-06-e01194Keywords:
Dendrimer, Drug therapy, Nanoscale, PAMAM, Pseudo Rotaxane, Targeted ReleaseAbstract
Nanoscale molecules known as dendrimers possess clearly defined, uniform, and monodisperse structures. They’re composed of a symmetrical core with an outside and interior shell. Due to their multiple beneficial features, dendrimers are an excellent choice in the medical field; this page compiles all of their different uses. Many different kinds of poly (propylene imine) and poly (amidoamine) dendrimers integrated with imatinib, sunitinib, cisplatin, melphalan, doxorubicin, paclitaxel, and methotrexate have shown advantages over the drug molecule alone. Dendrimers have undergone extensive research for their potential as anti-cancer agents. The mainstay of the inflammatory medicine was dendrimer complexes of indomethacin, piroxicam, ketoprofen ibuprofen, and diflunisal. Given the circumstances, the growth of bacterial strains resilient to antibiotics, fluoroquinolone, macrolide, beta-lactamine, and aminoglycoside dendrimer complexes have shown positive outcomes. In relation to treatment with antiviral drugs, There has been a study to create dendrimers being conjugated with tenofovir, maraviroc, zidovudine, oseltamivir, and other antivirals. Additionally, dendrimers have successfully allured much interest in cardiovascular medicine. Large, multi-component macromolecules constitute dendrimers. The present review enlists all kinds of related scientific and valuable aspects of dendrimers to help the researcher working with dendrimers.
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