EFFECTS OF BIFIDOBACTERIUM BREVE ON LIPID AND BMI IN METABOLIC SYNDROME: DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL
DOI:
https://doi.org/10.55766/sujst10940Abstract
Metabolic Syndrome (MetS) comprises a number of conditions arising due to particular malfunctions in the body’s metabolic system. The symptoms consist of abnormal glucose tolerance (glucose intolerance) and a high lipid profile. In Thailand, MetS has been found to be a major medical issue that is linked to other diseases such as cardiovascular diseases (CVDs), arteriosclerosis, and diabetes mellitus. There are 95,064 deaths per year across the country, equivalent to a death rate of 151.94 per 100,000 populations. Therefore, metabolic syndrome may be considered a major problem in Thailand. Objective: to study the effectiveness of using probiotics and food diet for 6 months to control BMI and biochemical measurements in people with MetS. The current research involved a randomized, case-control clinical trial using forty participants with MetS. The probiotic strains in this study included microencapsulated Bifidobacterium breve BRO3 and B632. Initially, measurements were taken for BMI and biochemical parameters, from the first month (M0) to 6 months (M6). The body composition measurements included BMI and blood pressure. The biochemical measurements included HbA1c, FBS, cholesterol, low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol. Overall, forty cases with MetS revealed differences for the treatment group, with a significant decrease in BMI (P = 0.019), HbA1c (P = 0.004), FBS (P = 0.006), TC (P = 0.004), TGs (P = 0.002), LDL-C (P = 0.003) and HDL-C (P = 0.014) which could be considered significant at P<0.05.
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