Pharmacological Effects of Thunbergia laurifolia Lindl. Extract on Gastric Ulceration in Rats

Linda Chularojanamontri; Natthakarn Chiranthanat; Kanjana Jaijoy; Suvara Wattanapitayakul; Urarat Nanna; Piyanuch Rojsanga; Thanes Fuangfoo; Seewaboon Sireeratawong

doi:10.59796/jcst.V15N2.2025.93

Authors

Linda Chularojanamontri Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathum Thani 12120, Thailand
Natthakarn Chiranthanat Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Kanjana Jaijoy McCormick Faculty of Nursing, Payap University, Chiang Mai 50000, Thailand
Suvara Wattanapitayakul Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
Urarat Nanna Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathum Thani 12120, Thailand
Piyanuch Rojsanga Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
Thanes Fuangfoo Department of Pharmacology, College of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand
Seewaboon Sireeratawong Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200

DOI:

https://doi.org/10.59796/jcst.V15N2.2025.93

Keywords:

anti-ulcerogenic activity, Thunbergia laurifolia Lindl, rang jeud, gastric lesion

Abstract

Thunbergia laurifolia Lindl. (TL), a medicinal plant renowned for its anti-inflammatory properties, has attracted interest in its potential antiulcerogenic effects. Gastric ulcers, typically resulting from an imbalance between aggressive factors such as gastric acid and the protective defenses of the gastric mucosa, are frequently aggravated by inflammatory processes. This study aimed to investigate the anti-ulcerogenic potential of TL extract in animal models. Male Sprague Dawley rats were selected for the study. The anti-ulcerogenic effects were evaluated using four distinct in vivo models: ethanol/hydrochloric acid administration, restraint water immersion stress, indomethacin administration, and pylorus ligation. Administration of TL extract at doses of 100, 200, and 400 mg/kg significantly reduced gastric ulcer formation induced by ethanol/hydrochloric acid as well as restraint water immersion stress. At doses of 200 and 400 mg/kg, the extract significantly reduced indomethacin-induced ulcer formation. Additionally, at a dose of 400 mg/kg, the extract significantly reduced both gastric secretion rate and total acidity in the pylorus ligation model. The findings of this study indicate that TL extract exhibits noteworthy anti-ulcerogenic activity in rats, suggesting its potential therapeutic value in treating gastric ulcers.

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