Synergism between natural product extracts and antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA)
Keywords:methicillin-resistant S. aureus, natural product extracts, synergism, MRSA
Staphylococcus aureus is recognized as one of the major infective agents causing both community and hospital acquired infections. Methicillin-resistant S. aureus (MRSA) is one of the multidrug resistant strains. Therefore, very few antibiotics are effective in treating infections caused by MRSA. Many compounds were synthesized and developed for the treatment of MRSA infections. In this study, twenty-five natural products, such as Capsicum flutescens L., Piper nigerum, Gracinia mangostana, Curcuma zanthorrhiza Roxb. , Aloe vera L., etc., were determined for antimicrobial activities. In addition, synergisms between these natural products and antibiotics were also studied. The results showed that bergamot oil demonstrated antibacterial activity against MRSA and Methicillin-susceptible S. aureus (MSSA). The MIC and MBC of bergamot oil against both strains were 0.39 mg/ml and 0.78 mg/ml, respectively. It was found that a combination of bergamot oil and tetracycline reduced the MIC and MBC of tetracycline which indicated that they worked synergistically against MRSA and MSSA.
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