Synergism between natural product extracts and antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA)


  • Acharawan Thongmee Department of Medical Science, Faculty of Science, Rangsit University, Patumthani 12000, Thailand
  • Patamaporn Sukplang Department of Medical Science, Faculty of Science, Rangsit University, Patumthani 12000, Thailand


methicillin-resistant S. aureus, natural product extracts, synergism, MRSA


Staphylococcus aureus is recognized as one of the major infective agents causing both community and hospital acquired infections.  Methicillin-resistant S. aureus (MRSA) is one of the multidrug resistant strains.  Therefore, very few antibiotics are effective in treating infections caused by MRSA.  Many compounds were synthesized and developed for the treatment of MRSA infections.  In this study, twenty-five natural products, such as Capsicum flutescens L., Piper nigerum, Gracinia mangostana, Curcuma zanthorrhiza Roxb. , Aloe vera L., etc., were determined for antimicrobial activities. In addition, synergisms between these natural products and antibiotics were also studied. The results showed that bergamot oil demonstrated antibacterial activity against MRSA and Methicillin-susceptible S. aureus (MSSA).  The MIC and MBC of bergamot oil against both strains were 0.39 mg/ml and 0.78 mg/ml, respectively. It was found that a combination of bergamot oil and tetracycline reduced the MIC and MBC of tetracycline which indicated that they worked synergistically against MRSA and MSSA.


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How to Cite

Acharawan Thongmee, & Patamaporn Sukplang. (2023). Synergism between natural product extracts and antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA). Journal of Current Science and Technology, 5(1), 19–25. Retrieved from



Research Article