Preparation and properties of poly(butylene succinate) porous scaffold by fused deposition modeling and salt leaching techniques

Kasidis Teerasuchai; Bussarin Ksapabutr; Manop Panapoy; Nattawut Chaiyut

Authors

Kasidis Teerasuchai Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand
Bussarin Ksapabutr Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand
Manop Panapoy Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand
Nattawut Chaiyut Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand

Keywords:

fused deposition modeling, poly(butylene succinate), porosity, porous scaffold, salt leaching, wettability

Abstract

Scaffolds are a promising innovation that create a suitable environment for the restoration of tissues. They can also be used to achieve efficient drug delivery to specific sites. Poly(butylene succinate) (PBS) is a biocompatible and biodegradable polymer that has been utilized in various research fields. Fused deposition modeling (FDM) was conducted to construct PBS scaffolds with two specific lay-down patterns: grid and triangle. The salt leaching technique was also used to produce pores in the scaffolds. A morphological study, porosity measurement, and contact angle analysis were carried out to characterize scaffold morphology, pore characteristics and surface properties. Salt content and type of lay-down patterns were found to affect the porosity and wettability of the scaffolds. Porosity increased with an increasing proportion of salt while scaffolds with a triangle pattern were more porous than grid pattern at the same salt content. The wettability test showed that the contact angle of all scaffolds ranged between 88° and 102°, while the grid pattern was more hydrophobic than the triangle pattern.

References

Biswas, A., Shukla, A., & Maiti, P. (2019). Biomaterials for interfacing cell imaging and drug delivery: An overview. Langmuir, 35(38), 12285-12305. DOI: https://doi.org/10.1021/acs.langmuir.9b00419

Choi, W. J., Hwang, K. S., Kwon, H. J., Lee, C., Kim, C. H., Kim, T. H., ... & Lee, J. Y. (2020). Rapid development of dual porous poly (lactic acid) foam using fused deposition modeling (FDM) 3D printing for medical scaffold application. Materials Science and Engineering: C, 110, 110693. DOI: https://doi.org/10.1016/j.msec.2020.110693

Etxabide, A., Long, J., Guerrero, P., de la Caba, K., & Seyfoddin, A. (2019). 3D printed lactose-crosslinked gelatin scaffolds as a drug delivery system for dexamethasone. European Polymer Journal, 114, 90-97. DOI: https://doi.org/10.1016/j.eurpolymj.2019.02.019

Gigli, M., Fabbri, M., Lotti, N., Gamberini, R., Rimini, B., & Munari, A. (2016). Poly(butylene succinate)-based polyesters for biomedical applications: A review. European Polymer Journal, 75, 431-460. DOI: https://doi.org/10.1016/j.eurpolymj.2016.01.016

Gorji, M., Zargar, A., Setayeshmehr, M., Ghasemi, N., Soleimani, M., Kazemi, M., & Hashemibeni, B. (2021). Releasing and structural/mechanical properties of nano-particle/Punica granatum (Pomegranate) in poly (lactic-co-glycolic) acid/fibrin as nano-composite scaffold. Bratislavske Lekarske Listy, 122(1), 54-64. DOI: https://doi.org/10.4149/bll_2021_007

Hu, C., & Qin, Q. H. (2020). Advances in fused deposition modeling of discontinuous fiber/polymer composites. Current Opinion in Solid State and Materials Science, 24(5), 100867. DOI: https://doi.org/10.1016/j.cossms.2020.100867

Huang, A., Peng, X., Geng, L., Zhang, L., Huang, K., Chen, B., ... & Kuang, T. (2018). Electrospun poly (butylene succinate)/cellulose nanocrystals bio-nanocomposite scaffolds for tissue engineering: Preparation, characterization and in vitro evaluation. Polymer Testing, 71, 101-109. DOI: https://doi.org/10.1016/j.polymertesting.2018.08.027

Ju, J., Gu, Z., Liu, X., Zhang, S., Peng, X., & Kuang, T. (2020). Fabrication of bimodal open-porous poly (butylene succinate)/cellulose nanocrystals composite scaffolds for tissue engineering application. International Journal of Biological Macromolecules, 147, 1164-1173. DOI: https://doi.org/10.1016/j.ijbiomac.2019.10.085

Kumar, R. M., Haldar, S., Rajesh, K., Ghosh, S., & Lahiri, D. (2019). Comparative study on the efficacy of the UHMWPE surface modification by chemical etching and electrostatic spraying method for drug release by orthopedic implants. Materials Science and Engineering: C, 105, 110117. DOI: https://doi.org/10.1016/j.msec.2019.110117

Li, D., Li, C., Wang, X., Li, C., Sun, T., Zhou, J., & Li, G. (2020). Facile fabrication of composite scaffolds for long-term controlled dual drug release. Advances in Polymer Technology, 2020, 10. DOI: https://doi.org/10.1155/2020/3927860

Liu, Y., & Guo, B. (2019). Preparation and characterisation of poly (butylene succinate) microcarriers containing pesticide. Micro & Nano Letters, 14(1), 81-85. DOI: https://doi.org/10.1049/mnl.2018.5060

Mondal, S., & Pal, U. (2019). 3D hydroxyapatite scaffold for bone regeneration and local drug delivery applications. Journal of Drug Delivery Science and Technology, 53, 101131. DOI: https://doi.org/10.1016/j.jddst.2019.101131

Obayemi, J. D., Jusu, S. M., Salifu, A. A., Ghahremani, S., Tadesse, M., Uzonwanne, V. O., & Soboyejo, W. O. (2020). Degradable porous drug-loaded polymer scaffolds for localized cancer drug delivery and breast cell/tissue growth. Materials Science and Engineering: C, 112, 110794. DOI: https://doi.org/10.1016/j.msec.2020.110794

Ojansivu, M., Johansson, L., Vanhatupa, S., Tamminen, I., Hannula, M., Hyttinen, J., ... & Miettinen, S. (2018). Knitted 3D scaffolds of polybutylene succinate support human mesenchymal stem cell growth and osteogenesis. Stem cells international, 2018. 11. DOI: https://doi.org/10.1155/2018/5928935

Platnieks, O., Gaidukovs, S., Barkane, A., Sereda, A., Gaidukova, G., Grase, L., ... & Laka, M. (2020). Bio-based poly (butylene succinate)/microcrystalline cellulose/nanofibrillated cellulose-based sustainable polymer composites: Thermo-mechanical and biodegradation studies. Polymers, 12(7), 1472. DOI: https://doi.org/10.3390/polym12071472

Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., ... & Khademhosseini, A. (2018). Drug delivery systems and materials for wound healing applications. Advanced drug delivery reviews, 127, 138-166. DOI: https://doi.org/10.1016/j.addr.2018.04.008.

Senthamizhan, A., Balusamy, B., Celebioglu, A., & Uyar, T. (2016). “Nanotraps” in porous electrospun fibers for effective removal of lead (II) in water. Journal of Materials Chemistry A, 4(7), 2484-2493. DOI: https://doi.org/10.1039/C5TA09166G

Szewczyk, P. K., Ura, D. P., Metwally, S., Knapczyk-Korczak, J., Gajek, M., Marzec, M. M., ... & Stachewicz, U. (2019). Roughness and fiber fraction dominated wetting of electrospun fiber-based porous meshes. Polymers, 11(1), 34. DOI: https://doi.org/10.3390/polym11010034

Visscher, L. E., Dang, H. P., Knackstedt, M. A., Hutmacher, D. W., & Tran, P. A. (2018) 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics. Materials Science & Engineering C, 87, 78-89. DOI: https://doi.org/10.1016/j.msec.2018.02.008

Water, J. J., Bohr, A., Boetker, J., Aho, J., Sandler, N., Nielsen, H. M., & Rantanen, J. (2015). Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. Journal of pharmaceutical sciences, 104(3), 1099-1107. DOI: https://doi.org/10.1002/jps.24305

Zhang, K., Fan, Y., Dunne, N., & Li, X. (2018). Effect of microporosity on scaffolds for bone tissue engineering. Regenerative biomaterials, 5(2), 115-124. DOI: https://doi.org/10.1093/rb/rby