We are not alone: melatonin and vitamin D may be good company during COVID-19 pandemic


  • Sebastián García Menéndez Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Mendoza, Argentina. and Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
  • Virna Margarita Martín Giménez Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Argentina
  • Russel J. Reiter Department of Cell Systems and Anatomy, UT Health San Antonio Long School of Medicine, San Antonio, TX, USA.
  • Walter Manucha Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Mendoza, Argentina. and Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.


anxiety, cognitive faculties, chronodisruption, depression, melatonin and vitamin D, SARS-CoV-2, social isolation


Loneliness and social isolation are associated with depression, anxiety and a progressive loss of higher cognitive faculties, mainly in older adults.  In the current pandemic situation, with serious restrictions that limit interactions with members of our social circles, these cognitive alterations are becoming progressively more obvious in young adults, adolescents and even children.  With the addition of eating disorders, sleep disturbances, and lack of exposure to solar radiation due to confinement, the condition can be considerably worse.  Fortunately, there are two allies which from a psychological point of view, have many common features and could help to reverse some of the effects of social isolation; these molecules are melatonin and vitamin D.  Their complementary functions on circadian rhythmicity may be useful in reestablishing mood balance.  Thus, we suggest a re-education in new hygienic-dietary habits, especially related to the maintenance of adequate levels of melatonin and vitamin D, which may help prevent and possibly reverse the cognitive and psychological disorders until social contact is reestablished.


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How to Cite

Sebastián García Menéndez, Virna Margarita Martín Giménez, Russel J. Reiter, & Walter Manucha. (2023). We are not alone: melatonin and vitamin D may be good company during COVID-19 pandemic. Journal of Current Science and Technology, 11(1), 158–170. Retrieved from https://ph04.tci-thaijo.org/index.php/JCST/article/view/367



Review Article