In Vitro Biological Activity of Tiliacora triandra (Colebr.) Diels Root Extract

Nalinee Pradubyat; Fameera  Madaka; Thanapat  Songsak; Suchada Jongrungruangchok

doi:10.59796/jcst.V15N1.2025.77

Authors

Nalinee Pradubyat Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
Fameera Madaka Sino-Thai Traditional Medicine Research Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
Thanapat Songsak Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
Suchada Jongrungruangchok Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand

DOI:

https://doi.org/10.59796/jcst.V15N1.2025.77

Keywords:

Tiliacora triandra, tiliacorinine, antioxidant, cytotoxic activity

Abstract

In this study, we explore the phytochemical properties of Tiliacora triandra (Colebr.) Diels, commonly known as Yanang, a herb traditionally used for treating fever and malaria. Our objective is to isolate and analyze bioactive compounds from T. triandra's root extract, with a specific focus on tiliacorinine (T1), assessing its antioxidant, and anticancer capabilities. The antioxidant activity of T. triandra extract (TTE) was evident, with IC₅₀ values of 196.32 ± 10.51 µg/mL and 88.22 ± 1.95 µg/mL in the DPPH and ABTS assays, respectively. The results also demonstrated that TTE and T1 had a significant cytotoxic effect, with IC₅₀ values varying in a concentration-dependent manner against A549 with the IC₅₀ of 48.25 μg/mL and 26.38 μg/mL, respectively. Additionally, both TTE and T1 displayed anti-inflammatory effects, with the most effective inhibition of nitric oxide production observed at a concentration of 40 μg/mL. This study underlines the potential of T. triandra, and its compound tiliacorinine in developing treatments with antioxidant, anti-inflammatory, and anticancer properties.

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