Evaluation of the interaction of phenolic compounds contained in the Trisamo recipe using simplex lattice design

Jirapornchai  Suksaeree; Chaowalit  Monton

Authors

Jirapornchai Suksaeree Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Patumthani 12000, Thailand
Chaowalit Monton Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Patumthani 12000, Thailand

Keywords:

chemical interaction, optimization, phenolic compound, simplex lattice design, Terminalia plants, Trisamo

Abstract

This work sought to apply the simplex lattice design to determine the interaction between Terminalia chebula Retz. var. chebula, Terminalia arjuna Wight and Arn., and Terminalia bellirica (Gaertn.) Roxb., which are found in the traditional Trisamo recipe. The phenolic compounds gallic acid, corilagin, chebulagic acid, and chebulinic acid were analyzed using validated high-performance liquid chromatography. The results showed that a broader range of positive interaction was found in the decoction samples as opposed to the infusion samples. Moreover, it was determined that the original Trisamo recipe, which boasts an equal weight ratio of all three Terminalia plants, obtained from the decoction, exhibited a 250% increase in total content of the phenolic compounds as compared with the effects of any of the plants individually, while the original Trisamo recipe obtained from the infusion group revealed a 200% increase in total content of the phenolic compounds when compared with the results of an individual plant. Data from this work could be used to describe the synergism of plant compositions of Trisamo based on the chemical interactions, by enhancing extraction efficiency of total phenolic compounds. Moreover, they may support that the use of the Trisamo with an equal weight ratio distribution of the three Terminalia plants is in fact already appropriate.

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