Effectiveness of The Modified Formula of Ya-Tha-Pra-Sen on Relieving Neck and Shoulder Muscle Pain: Clinical Randomize Control Trail.
Keywords:Pain relief gel, herbal extracts, Ya-Tha-Pra-Sen, reducing muscle pain, Thai traditional
Ya-Tha-Pra-Sen (YTPS) has been utilized as a topical remedy to alleviate muscle pains since the Ayutthaya period. Formulated from a combination of 13 distinct herbs, YTPS offers a range of medicinal properties. This study aimed to develop an enhanced YTPS gel formula, referred to as YTPS-DG, by incorporating an additional 5 traditional Thai herbs. The efficacy of YTPS-DG in reducing muscle pains was then compared with the traditional YTPS formula. A randomized controlled trial was undertaken with 45 participants, aged 20 to 60. Participants were randomly assigned to one of three groups: the YTPS-DG group (modified formula), the YTPS-TG group (traditional formula), or the placebo group (PCBG). Each participant received gel samples packaged in 2.5 g units and was instructed to apply one package's worth to their upper trapezius muscle twice daily over a span of six days. Daily results were systematically documented in case record forms, and participants were monitored with follow-up checks every three days. Our findings revealed that YTPS-DG exhibited the most pronounced efficacy. There was a statistically significant reduction in pain from baseline for the YTPS-DG group (P<0.05) when compared to the YTPS-TG and placebo groups. Furthermore, YTPS-DG notably increased weight-bearing capacity (in kg) and enhanced the Range of Motion (ROM) in participants' neck and shoulder areas, as demonstrated by comparing results before and after application. In conclusion, the modified YTPS-DG formula proved to be superior in alleviating muscle pains and enhancing functional parameters compared to the traditional YTPS and placebo. Further studies are warranted to explore the underlying mechanisms and potential applications.
Benjumea, D. M., Gómez-Betancur, I. C., Vásquez, J., Alzate, F., García-Silva, A., & Fontenla, J. A. (2016). Neuropharmacological effects of the ethanolic extract of Sida acuta. Revista Brasileira de Farmacognosia, 26, 209-215. https://doi.org/10.1016/j.bjp.2015.09.011
Cohen, J. (1988). Statistical Power Analysis for the Behavioral Science (2nd ed). US: Lawrence Erlbaum associates.
da Silva, S. P., Fernandes, J. A. L., Santos, A. S., & Ferreira, N. R. (2023). Jambu Flower Extract (Acmella oleracea) Increases the Antioxidant Potential of Beer with a Reduced Alcohol Content. Plants, 12(8), Article 1581. https://doi.org/10.3390/plants12081581
Dosoky, N. S., Satyal, P., Gautam, T. P., & Setzer, W. N. (2016). Composition and biological activities of Murraya paniculata (L.) Jack essential oil from Nepal. Medicines, 3(1), Article 7. https://doi.org/10.3390/medicines3010007
Hou, C. W., Lee, Y. C., Hung, H. F., Fu, H. W., & Jeng, K. C. (2012). Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity. The American journal of Chinese medicine, 40(05), 979-991. https://doi.org/10.1142/S0192415X12500723
Huang, G. J., Wang, B. S., Lin, W. C., Huang, S. S., Lee, C. Y., Yen, M. T., & Huang, M. H. (2012). Antioxidant and anti-inflammatory properties of longan (Dimocarpus longan Lour.) pericarp. Evidence-Based Complementary and Alternative Medicine, 2012, Article 709483 https://doi.org/10.1155/2012/709483
Kanokkangsadal, P., Waipradab M., Toonsakul P., Kanlamyai, K., Khun-anake, R., & Itharat, A. (2020). Clinical efficacy and safety of Ya-Ta-Pra-Sen in treating primary osteoarthritis of knee compared with analgesic cream an open label randomized controlled trial. Thai Journal of Pharmacy Practice, 12(3), 880-890.
Kingkaew, W. M., (2016). An Analytical study of the impact caused by the myofascial pain syndrome: MPS. Journal of Allied Health Sciences Suan Sunandha Rajabhat University, 1(1), 12-29.
Meekai, N., Junto, E., Saelee, K., & Komnais, K. (2021). Efficacy of Ya-Tha-Pra-Sen in Relieving Frozen Shoulder Pain. Journal of Traditional Thai Medical Research, 7(2), 17-29.
Ministry of Public Health. (n.d.). Textbook of Narayana Medication. Retrieved June 5, 2023, from https://dmsic.moph.go.th/index/detail/7386
Pillai, L. S., & Nair, B. R. (2014). In-vitro anti-inflammatory studies in Cleome viscosa L. and Cleome burmanni W. & A. (Cleomaceae). International Journal of Pharmaceutical Sciences and Research, 5(11), 4998-5003. http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4998-03
Roiet, M. N., Buakoom, P., Jitwuttiwas, P., & Wanthong, U. (2019). Preliminary effectiveness of ya-tha-pra-sen for pain reducing in Thai traditional diagnosis of lom-jub-pong-hang-kao. Journal of Traditional Thai and Alternative Medicine, 17(3), 447-459.
Sethpitak, T. (2015). The study of work conditions that contribute to the severity of computer syndrome [Master Thesis]. Faculty of Commerce and Accountancy Thammasat University, Thailand.
Tansathien, K., Dechsri, K., Opanasopit, P., Nuntharatanapong, N., Sukma, M., & Rangsimawong, W. (2022). Investigation of lipid nanocarriers and microspicule gel for dermal delivery of porcine placenta extract. Journal of Current Science and Technology, 12(3), 505-516. http://doi/10.14456/jcst.2022.39
Tcheghebe, O. T., Seukep, A. J., & Tatong, F. N. (2017). Ethnomedicinal uses, phytochemical and pharmacological profiles, and toxicity of Sida acuta Burm. F.: A review article. The Pharma Innovation, 6(6), 1-6.
Toelang, J., Jaisin, D., & Kornaew, K. (2017). Gel preparation development from Thai medicinal formularies for analgesic pharmacopeia [Conference presentation]. The 1st National Conference Research and Innovation Knowledge transformation towards Thailand 4.0, Mae Fah Luang University, Chiang Rai, Thailand.
Yarrappagaari, S., Thopireddy, L., Cheemanapalli, S., Narala, V. R. R., Mohan, K. C., & Saddala, R. R. (2022). Phytochemical Analysis of Cleome viscosa Active Polyphenolic Compounds Possessing Antidiabetic Activity. Pharmacognosy Research, 14(2), 195-203. https://doi.org/10.5530/pres.14.2.28
Zhou, M., Sangchan, H., & Sae-sia, W. (2022). Effect of preoperative self-efficacy pain education program on self-efficacy to report pain, pain intensity, and pain interferences among patients undergoing oral and maxillofacial surgery. Journal of Current Science and Technology, 12(2), 265-273. http://doi/10.14456/jcst.2022.19
Zou, J., Sui, D., Fu, W., Li, Y., Yu, P., Yu, X., & Xu, H. (2021). Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack alleviate oxidative stress, inflammation and apoptosis in a rat model of diabetic cardiomyopathy. Journal of Functional Foods, 76, Article 104319. https://doi.org/10.1016/j.jff.2020.104319
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