Aloe: medicinal properties and botanical characteristics


  • Domenico Prisa CREA Research Centre for Vegetable and Ornamental Crops, Via Dei Fiori 8, 51012 Pescia, Italy


aloe chemistry, aloe history, biodiversity, medicinal plants, medicinal properties, sustainable agriculture


Aloe plants have been studied and used to treat many diseases for thousands of years. Since ancient times it has been used to cure human ailments. Over the last few decades, several studies have shed light on the characteristics of this plant, which seems to want to hide its secrets behind botanical and pharmacological riddles that are only now beginning to be answered. The medicinal abilities of Aloe plants have been known to man since ancient times. Therefore, we can consider Aloe a food and medicine: if you decide to take Aloe, know that you have opted for complete food. Aloe plants are a reservoir of important substances for the human body, particularly vitamins, catalyzing enzymes, sugars and medicinal oils. The German Pharmacopoeia, in its 1873 edition, at the time of Bismark, already recorded more than 300 pharmaceutical elements contained in Aloe. Modern medical literature confirms this today, with lists and lists of such ingredients, the result of research by laboratories working honestly, objectively seeking the truth. Studies show the presence of certain secondary metabolites in Aloe that can cause problems. In particular, the presence of aloin, in Aloe vera, is a compound that can be metabolised by the human gut and can cause various harmful effects such as carcinogenic, genotoxic, nephrotic and digestive problems. The presence of certain alkaloids and polysaccharides are also reported to cause liver and reproductive problems. This paper examines the botanical, cultivation and medicinal properties associated with this very important plant.


Abouelela, M. E., Assaf, H. K., Abdelhamid, R. A., Elkhyat, E. S., Sayed, A. M., Oszako, T., ... & Abdelkader, M. S. A. (2021). Identification of potential SARS-CoV-2 main protease and spike protein inhibitors from the genus aloe: An in silico study for drug development. Molecules, 26(6), 1767.

Adeleye, O. A., Femi-Oyewo, M. N., Bamiro, O. A., Bakre, L. G., Alabi, A., Ashidi, J. S., ... & Fakoya, G. (2021). Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019. Future journal of pharmaceutical sciences, 7(1), 1-14.

Álvares, L. O. T., Martins Neto, E. S., Leite, G. M. O., Dórea, M. A., Barros, E. M. N., de Andrade, M. C., de Oliveira, M. S. (2018). Effects of Aloe vera on the healing of skin flaps in oophorectomized rats. Surgical & Cosmetic Dermatology, 10, 230.

Arora, M. K., Sarup, Y., Tomar, R., Singh, M., & Kumar, P. (2019). Amelioration of diabetes-induced diabetic nephropathy by Aloe vera: Implication of oxidative stress and hyperlipidemia. Journal of dietary supplements, 16(2), 227-244.

Atanu, F. O., Avwioroko, O. J., & Momoh, S. (2018). Anti-diabetic effect of combined treatment with Aloe vera gel and Metformin on alloxan-induced diabetic rats. Journal of Ayurvedic and Herbal Medicine, 4(1), 1-5.

Babu, S. N., & Noor, A. (2020). Bioactive constituents of the genus Aloe and their potential therapeutic and pharmacological applications: A review. Journal of Applied Pharmaceutical Science, 10(11), 133-145. DOI: 10.7324/JAPS.2020.101118

Banerjee, N., Chatterjee, S., Chatterjee, S., Bhattacharjee, S., Bhattacharya, B. & Mukherjee, S. (2018). Health Benefits of Aloe vera: A Review. Sci Cult, 84(9-10), 339-343.

Banik, S., & Sharangi, A. B. (2019). Phytochemistry, health benefits and toxicological profile of Aloe. J Pharmacog Phytochem, 8(3), 4499-4506.

Bhoye, S. K., Somkuwar, A. P., Sarode, K. G., Dubey, S. A., & Harke, M. P. (2021). Effect of Aloe vera gel and mint tea on letrozole induced PCOS in rat model. Journal of Pharmacognosy and Phytochemistry, 10(3), 494-499.

Boudreau, M. D., & Beland, F. A. (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C, 24(1), 103-154.

Choudhri, P., Rani, M., Sangwan, R. S., Kumar, R., Kumar, A., & Chhokar, V. (2018). De novo sequencing, assembly and characterisation of Aloe vera transcriptome and analysis of expression profiles of genes related to saponin and anthraquinone metabolism. BMC genomics, 19(1), 1-21.

Debnath, T., Ghosh, M., Lee, Y. M., Nath, N. C. D., Lee, K. G., & Lim, B. O. (2018). Identification of phenolic constituents and antioxidant activity of Aloe barbadensis flower extracts. Food and Agricultural Immunology, 29(1), 27-38.

Dziewulska, D., Stenzel, T., Śmiałek, M., Tykałowski, B., & Koncicki, A. (2018). The impact of Aloe vera and licorice extracts on selected mechanisms of humoral and cell-mediated immunity in pigeons experimentally infected with PPMV-1. BMC veterinary research, 14(1), 1-11.

Feinberg, S., Williams, R., Hagler, G. S., Rickard, J., Brown, R., Garver, D., ... & Garvey, S. (2018). Long-term evaluation of air sensor technology under ambient conditions in Denver, Colorado. Atmospheric measurement techniques, 11(8), 4605-4615.

Gansukh, E., Gopal, J., Paul, D., Muthu, M., Kim, D. H., Oh, J. W., & Chun, S. (2018). Ultrasound mediated accelerated Anti-influenza activity of Aloe vera. Scientific reports, 8(1), 1-10.

Giannakoudakis, D. A., Hosseini-Bandegharaei, A., Tsafrakidou, P., Triantafyllidis, K. S., Kornaros, M., & Anastopoulos, I. (2018). Aloe vera waste biomass-based adsorbents for the removal of aquatic pollutants: A review. Journal of environmental management, 227, 354-364.

Grindlay, D., & Reynolds, T. (1986). The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. Journal of ethnopharmacology, 16(2-3), 117-151.

Gulati, P., College, M. G., & Sahib, F. (2021). A review on medicinal properties of Aloe vera plant and it’s profile. International Research Journal of Modernization in Engineering Technology and Science, 5, 22.

Haroon, S. M., Shahid, S., Hussain, S. A., & Raza, H. (2018). Comparative study of antioxidant activity of flower of Aloe vera and leaf extract of Aloe ferox. Journal of Basic & Applied Sciences, 14, 191-196.

Heng, H. C., Zulfakar, M. H., & Ng, P. Y. (2018). Pharmaceutical applications of Aloe vera. Indonesian Journal of Pharmacy, 29(3), 101-116. DOI: 10.14499/indonesianjpharm29iss3pp101

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., ... & Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. cell, 181(2), 271-280.

Ibrahim, A. M., Al Sadah, H., Ahmad, R., Ahmad, N., & Naqvi, A. A. (2019). Clinical Uses and Toxicity of Aloe vera: An Evidence-Based Comprehensive Retrospective Review (2007-2017). Pharmacognosy Journal, 11(2), 424-428. DOI:10.5530/pj.2019.11.66

Kar, S. K. & Bera, T. K. (2018). Phytochemical constituents of Aloe vera and their multifuctional properties: a comprehensive review. Int J Phar Sci Res, 9, 1416- 1423.

Karpagam, T., Sugunabai, J., Gomathi, S. & Muhamad, N. (2019). Phytochemical study in ethanolic leaves extract of Aloe vera using Gas chromatography. International Journal of Research in Pharmaceutical Sciences, 10(2),1470–1473. DOI:10.26452/ijrps.v10i2.720

Khan, S. L., & Siddiqui, F. A. (2020). Beta-Sitosterol: as immunostimulant, antioxidant and inhibitor of SARS-CoV-2 spike glycoprotein. Archives of Pharmacology and Therapeutics, 2(1), 12-16.

Liang, J., Cui, L., Li, J., Guan, S., Zhang, K., & Li, J. (2021). Aloe vera: a medicinal plant used in skin wound healing. Tissue Engineering Part B: Reviews, 27(5), 455-474.

López, Z., Femenia, A., Núñez-Jinez, G., Salazar Zúñiga, M. N., Cano, M. E., Espino, T., & Knauth, P. (2019). In vitro immunomodulatory effect of food supplement from Aloe vera. Evidence-based Complementary and Alternative Medicine, 2019, 1-9.

Luta, G., & McAnalley, B. (2005). Aloe vera: chemical composition and methods used to determine its presence in commercial products. GlycoScience & Nutrition, 6, 1-12.

Meshram, M., Bhowate, R. R., Madke, B., & Sune, R. (2018). Evaluation of the Effect of Ultrasound Physiotherapy Interventions in Combination with Local Application of Aloe-Vera and Turmeric Gel in the Management of Oral Submucous Fibrosis. Journal of Dental Investigation, 1(1), 16-33.

Miramon-Ortíz, D. A., Argüelles-Monal, W., Carvajal-Millan, E., López-Franco, Y. L., Goycoolea, F. M., & Lizardi-Mendoza, J. (2019). Acemannan gels and aerogels. Polymers, 11(2), 330.

Moradi, B., Abbaszadeh, S., Shahsavari, S., Alizadeh, M., & Beyranvand, F. (2018). The most useful medicinal herbs to treat diabetes. Biomedical research and therapy, 5(8), 2538-2551.

Park, Y. I., & Jo, T. H. (2006). Perspective of industrial application of Aloe vera. In New perspectives on Aloe (pp. 191-200). Boston, MA: Springer

Prakoso, Y. A., Setiyo Rini, C., & Wirjaatmadja, R. (2018). Efficacy of Aloe vera, Ananas comosus, and Sansevieria masoniana Cream on the Skin Wound Infected with MRSA. Advances in pharmacological sciences, 2018.

Prisa, D., & Gobbino, M. (2021a). Microbic and Algae biofertilizers in Aloe barbadensis Miller. Open Access Research Journal of Biology and Pharmacy, 1(2), 1-9.

Prisa, D., & Gobbino, M. (2021b). Biological treatments for quality improvement and production of Aloe vera gel. GSC Advanced Research and Reviews, 9(1), 054-063.

Prisa, D., & Gobbino, M. (2021c). Sustainable Methods Based on Microbial Biofertilizers and Plant Repellent Extracts in the Cultivation of Aloe Vera. World, 10(4), 27-32.

Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., ... & Peng, C. (2019). Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology Letters, 306, 66-79.

Rehman, N. U., Al-Riyami, S. A., Hussain, H., Ali, A., Khan, A. A. L., & Al-Harrasi, A. (2019). Secondary metabolites from resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation. Acta Pharmaceutica, 69(3), 433-441.

Saleh, M. Y., Chaturvedi, S., Ibrahim, B., Khan, M. S., Jain, H., Nama, N., & Jain, V. (2019). Hearbal detox extract formulation from seven wonderful natural herbs: garlic, ginger, honey, carrots, aloe vera, dates, & corn. Asian Journal of Pharmaceutical Research and Development, 7(3), 22-30.

Sánchez, M., González-Burgos, E., Iglesias, I., & Gómez-Serranillos, M. P. (2020). Pharmacological update properties of Aloe vera and its major active constituents. Molecules, 25(6), 1324.

Sánchez-Machado, D. I., López-Cervantes, J., Sendón, R., & Sanches-Silva, A. (2017). Aloe vera: Ancient knowledge with new frontiers. Trends in Food Science & Technology, 61, 94-102.

Sharma, N., Minocha, N. & Kushwaha, N. (2020). A review on the activities of Aloe vera and curry leaves. International Journal of Recent Scientific Research, 11(11):12-17.

Shi, X. D., Yin, J. Y., Zhang, L. J., Li, O. Y., Huang, X. J., & Nie, S. P. (2019). Studies on polysaccharides from leaf skin of Aloe barbadensis Miller: Part II. Structural characteristics and molecular properties of two lower molecular weight fractions. Food Hydrocolloids, 86, 50-61.

Sobrinho, O. P. L., Pereira, Á. I. S., Cantanhede, E. D. K. P., dos Santos Xavier, R., dos Santos Oliveira, L., Pereira, A. D. G. S., & Cruz, C. H. G. (2018). Estudo etnobotânico de plantas medicinais e indicações terapêuticas no povoado Fomento, município de Codó, Maranhão, Brasil. Revista Cubana de Plantas Medicinales, 23(1).

Steenkamp, V., & Stewart, M. J. (2007). Medicinal applications and toxicological activities of Aloe. Products. Pharmaceutical biology, 45(5), 411-420.

Sudhakar, P., Prabhu, V. V., Jamuna, B., Adithya, R. S., Joy, A., & Anand, R. (2018). Preclinical toxicological evaluation of Aloe vera health drinks in Wistar rats. International Journal of Research in Pharmaceutical Sciences and Technology, 1(1), 27-32.

Thakur, N. S., Jilariya, D. J., Gunaga, R. P., & Singh, S. (2018). Positive allelospoly of Melia dubia Cav. spatial geometry improve quantitative and qualitative attributes of Aloe vera L. Industrial Crops and Products, 119, 162-171.

Toro, A. M., Munhões, R. A. C., Camilo, B. G., Vale, E., Baldini, R., & Pasa, M. C. (2018). Levantamento etnobôtanico da planta medicinal Aloe vera L. na comunidade São Gonçalo Beira Rio, Cuiabá, MT. Biodiversidade, 17(1), 80-88.

Uda, M. N. A., Gopinath, S. C., Ibrahim, N. H., Hashim, M. K. R., Nuradibah, M. A., Salimi, M. N., ... & Hashim, U. (2018). Preliminary Studies on Antimicrobial Activity of Extracts from Aloe Vera Leaf, Citrus Hystrix Leaf, Zingiber Officinale and Sabah Snake Grass Against Bacillus Subtilis. In MATEC Web of Conferences. EDP Sciences.

Wu, C., Liu, Y., Yang, Y., Zhang, P., Zhong, W., Wang, Y., ... & Li, H. (2020). Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharmaceutica Sinica B, 10(5), 766-788.

Yadav, K., Ghadge, P., Langeh, A., Kalbhare, S., Phadtare, P., & Bhoite, R. (2020). A review on herbal medicinal plant for treatment of polycystic ovarian syndrome (PCOS). Asian Journal of Pharmaceutical Research and Development, 8(4), 83-87.

Yamaguchi, I., Mega, N., & Sanada, H. (1993). Components of the Gel of Aloe vera (L.) Bunn. f. Bioscience, biotechnology, and biochemistry, 57(8), 1350-1352.

Yohannes, G. (2018). review on medicinal value of Aloe vera in veterinary practice. Biomedical Journal of Scientific and Technical Research, 6(1), 1-6.




How to Cite

Domenico Prisa. (2023). Aloe: medicinal properties and botanical characteristics. Journal of Current Science and Technology, 12(3), 605–614. Retrieved from