Suranaree Journal of Science and Technology

EXPLORING THE INTERPLAY OF LIFESTYLE, PSYCHOLOGICAL AND HEALTH FACTORS IN SPECIFIC LOW BACK PAIN: A COMPREHENSIVE CORRELATIONAL ANALYSIS

Reeta Sharma — 2024-08-09

Background: Low back pain is a major health concern in India, with studies reporting a lifetime prevalence ranging from 48% to 59%. This condition significantly impacts a large segment of the population, affecting quality of life by disrupting sleep, psychological well-being, and social interactions. Among the various causes of low back pain, one frequently encountered condition is degenerative disc disease, also known as lumbar disc herniation or prolapsed intervertebral disc (PIVD). The chronic pain and physical limitations associated with PIVD profoundly impact patients’ lifestyles, leading to substantial reductions in physical activity, challenges in performing daily tasks, and decreased work capacity. These limitations often result in social isolation and a diminished quality of life. Objective: To investigate and elucidate the intricate relationships between lifestyle, psychological and health-related factors in individuals specifically suffering from low back pain. Method: 80 patients with PIVD who fulfilled the inclusion and exclusion criteria were recruited from the Orthopaedic and Physiotherapy OPD. The data was collected by the interview method for their responses based on the Questionnaires and Body composition was analysed for Health related factors. Result and Conclusion: The study suggests that there is a significant relationship between lower back pain and lifestyle factors such as sleep quality and physical activity. Other unexplored factors may play a more influential role in lower back pain. Additionally, a weak negative correlation exists between lower back pain and psychological factors measured by the Beck Depression Inventory (BDI). The analysis reveals a weak positive correlation between lower back pain and physical functioning, while a significant negative correlation is observed between lower back pain and role limitations due to physical health. This suggests that higher levels of lower back pain may result in greater restrictions in physical health-related roles.

FORMULATION OF AN EMULGEL LOADING A SYNERGISTIC ANTIBACTERIAL COMBINATION OF α-MANGOSTIN ENRICHED EXTRACT AND LAWSONE METHYL ETHER

Saravoot Pumjan — 2024-08-15

This study aimed to formulate a stable topical emulgel containing a synergized anti-methicillin-resistant Staphylococcus aureus (MRSA) combination of α-mangostin enriched extract (AME) and lawsone methyl ether (LME). AME (containing 84.9% w/w α-mangostin) was prepared using green technology, while pure LME was semi-synthesized from lawsone. Synergistic antibacterial effects against MRSA were evaluated using a broth microdilution assay coupled with the checkerboard method. Four AME and LME-loaded emulgels (F1–F4) containing 0.025% w/w AME and 0.2% w/w LME were formulated and evaluated for their physical, chemical, and biological stabilities under accelerated conditions for 6 months. The antibacterial assay followed by the checkerboard method revealed the best synergistic anti-MRSA effect between AME and LME at concentrations of 0.5 and 4 µg/mL, respectively. Based on the stability evaluations, the F4 formula exhibited good physical, chemical, and biological stabilities for at least 6 months. These results indicate that the emulgel containing a synergistic cocktail of 0.025% w/w AME and 0.2% w/w LME possesses high potential for further in vivo studies on the treatment of wounds associated with MRSA infection.

DESIGN OF AREA & POWER EFFICIENT MGDI FULL ADDER USING POWER GATING TECHNIQUE

Deepika M — 2024-08-15

Full adders are utilized in many different appeals, in digital signal processors, microprocessors & microcontrollers, and are an essential component of the design of many digital systems. Great control is needed in electronic devices and circuits, which necessitates low power and rapid processing. The power gated MGDI complete full adder style analysis and design are displayed. Some low power complexity is retained in this entire adder. The presentation and appeal of MGDI full adder with existing adders, such as GDI and M-GDI. The solution of the power gated- MGDI full-adder demonstrated better power analysis values. Low power dissipation is decreased by using the MGDI Method while designing circuits. A MGDI approach enhances the threshold voltage drop and overcomes weak voltage swing output. Power gating is a method used in IC design to minimize power utilization by switching off the current to this circuit lumps, that are bared. The entire adder was constructed utilizing 45 nm technology and the Cadence tool's toggle drawing mode. It is based on the Power Gated- MGDI. The solution of power analysis obtained is 17.61uW & delay of 21.25e-9. It achieved 96.07%,87.6%,87.3, 83.7% & 78.8% for Conventional full adder,10T-GDI, 16T-Hybrid, 14T-MVT-GDI and 8T-M-GDI Technique. It achieved delay of 89.5%, 50%,50.5%93% &17.95% for Conventional full adder,10T-GDI, 16T-Hybrid, 14T-MVT-GDI and 8T-M-GDI Technique. The construction of full adders for effective arithmetic operations and the installation of MASH and modulators for Sigma Delta DACs are two contemporary applications of the GDI technique that are also examined in this work.

HISTOLOGICAL AND HISTOCHEMISTRY COMPARISONS BETWEEN MEDIAL AND LATERAL MENISCI IN OSTEOARTHRITIS PATIENTS

Piyachat Rungsawang — 2024-08-26

Osteoarthritis (OA) is a joint disease affecting articular cartilage, menisci, and other joint components. The main objective of this study was to investigate structural and biochemical changes in the medial and lateral menisci of Thai OA patients. Histologically, the bone marrow-like structure was mainly observed at the posterior horn of both medial and lateral menisci. The numbers of meniscal cells were significantly lower at the posterior and anterior horns of the medial and menisci, respectively. Cells at the posterior horn of the medial meniscus were significantly hypertrophied. A decrease in proteoglycan was observed mainly at the posterior horn of both medial and lateral menisci, while collagen fibers markedly increased at the posterior horn of the medial meniscus. Moreover, apoptotic cells were significantly higher in numbers at the posterior and anterior horns of the lateral and medial menisci respectively. The results revealed that the pathology of OA occurred mostly at the posterior horn of the medial meniscus.